Attenuated Atherosclerotic Lesions in apoE-Fcg Chain-Deficient Hyperlipidemic Mouse Model Is Associated with Inhibition of Th17 Cells and Promotion of Regulatory T Cells
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Attenuated atherosclerotic lesions in apoE-Fcγ-chain-deficient hyperlipidemic mouse model is associated with inhibition of Th17 cells and promotion of regulatory T cells.
Though the presence of antioxidized low-density lipoprotein IgG is well documented in clinical and animal studies, the role for FcγRs to the progression of atherosclerosis has not been studied in detail. In the current study, we investigated the role for activating FcγR in the progression of atherosclerosis using apolipoprotein E (apoE)-Fcγ-chain double-knockout (DKO) mice. Relative to apoE kno...
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